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VOL. 10, ISSUE 7 (2025)
A comprehensive evaluation of the diuretic and antihypertensive properties of Lippia nodiflora (L.) greene (Verbenaceae) in experimental models
Authors
Tanuja Jha, MN Reddy, FM Parabia
Abstract
Hypertension and fluid retention-related disorders, such as edema and
congestive heart failure, require effective management strategies, often
relying on diuretics and antihypertensive agents. The present study
investigated the diuretic and antihypertensive potential of Lippia nodiflora
(LN) aqueous and ethanolic extracts in Wistar albino rats over multiple time
points (5 hours, 24 hours, 7 days, 14 days, and 21 days). The diuretic activity
of LN extracts was dose-dependent, with the 500 mg/kg dose demonstrating the
most significant effects. LN-treated groups exhibited increased urine output,
particularly at 7 days (9.17 ± 0.85 mL compared to 4.17 ± 0.62 mL in the
control group), along with enhanced sodium (319.97 ± 2.86 mmol/L) and chloride
(170.03 ± 0.39 mmol/L) excretion. Strong natriuretic and saluretic activity was
observed, with minimal impact on potassium and calcium levels, indicating a
favourable safety profile for prolonged use. The antihypertensive effects of LN
extracts were equally remarkable, showing substantial reductions in systolic,
diastolic, and mean arterial blood pressures in DOCA-induced hypertensive rats.
The highest dose (450 mg/kg) of LN reduced systolic blood pressure to 146 ±
6.27 mmHg, diastolic blood pressure to 101 ± 7.04 mmHg, and mean arterial
pressure to 123 ± 2.42 mmHg, demonstrating its efficacy in managing
hypertension. These findings highlight Lippia nodiflora as a promising
natural alternative for managing hypertension and fluid retention disorders.
Future research focusing on its active compounds and clinical efficacy in
humans is essential to validate its therapeutic potential.
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Pages:31-40
How to cite this article:
Tanuja Jha, MN Reddy, FM Parabia "A comprehensive evaluation of the diuretic and antihypertensive properties of <i>Lippia nodiflora</i> (L.) greene (Verbenaceae) in experimental models". International Journal of Botany Studies, Vol 10, Issue 7, 2025, Pages 31-40
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