The indiscriminate application of antimicrobial compounds has gained lot of attention wjich are able to cause global health issues, which is outcome of bacterial resistance. The present research focused on the antimicrobial and free radical efficacies of polar extracts of the two medicinal plants Derris elliptica and Ailanthus excels on various clinical isolates. Both plants were sequentially portioned in different solvents, at different dose level. The free radical scavenging was studied using the DPPH assay. In D. elliptica against E. coli we found that both chloroform and methanolic extracts of bark showed better activity (IZ-14mm) as compared to leaves. Against S. aureus the observations were in contrast to earlier as leaves had better efficacy (IZ -14mm) as compared to bark. Against P. aeruginosa highest potency found in methanolic fraction of leaves (IZ -16mm) while against B. subtilis partial efficacy was found in some cases. In fungal efficacy when extracts were tested against C. albicans it was observed that maximum efficacy was in methanolic extracts of leaves (IZ-12mm) while in chloroform extracts activity was at par both in leaves and bark. Against P. chrysogenum maximum efficacy found in chloroform fraction of leaves (IZ-14mm) while against A. niger resistivity was found in both parts. Against F. moniliforme maximum efficacy found in chloroform fraction of bark (IZ-16 mm). In A. excelsa when extracts were tested against different bacterial strains were studied activity was lower as compared to D. elliptica

It was observed that against E. coli methanolic extracts of leaves and bark have at par activity (IZ-12 mm) while chloroform extract of bark did not show any activity. Against S. aureus maximum activity (IZ-16 mm) was observed in chloroform extracts of leaves while no activity was observed in methanolic extracts.

Against P. aeruginosa no activity was observed in any sample so it was found to be resistant while in B. subtilis maximum efficacy (IZ-18mm) was observed in methanolic extracts of bark.

In case of fungal efficacy, it was observed that against C. albicans both methanolic and chloroform extract of leaves had potent activity while in bark no efficacy was observed. Maximum activity was observed in chloroform extract of leaves (IZ-10mm). Against P. chrysogenum except chloroform extracts of leaves no activity was observed in any sample thus it was found to be resistant. Further against A. niger moderate efficacy was observed in both chloroform and methanolic extracts of leaves (IZ-8 and 6mm). Against F. moniliforme at par efficacy was observed in chloroform extracts of leaves and bark (IZ-12mm each).