The present study investigates the ethnobotanical significance and phytochemical composition of Leucas cephalotes (Roth) Spreng., (Dronpushpi), a widely used medicinal herb among indigenous communities of Rewa district, Madhya Pradesh. Traditional healers and tribal populations rely on this species for treating fever, cough, wounds, skin infections, inflammation, and digestive disorders. Ethnobotanical data were collected through field surveys, interviews, and participatory observation involving local informants, including herbal practitioners and elderly community members. Plant samples were collected, identified, and subjected to preliminary phytochemical screening using standard qualitative methods. The results revealed the presence of major bioactive constituents such as alkaloids, flavonoids, tannins, saponins, phenols, terpenoids, and glycosides. The study validates the traditional therapeutic uses of Leucas cephalotes and highlights its potential for pharmacological research and conservation. Documentation of such indigenous knowledge is crucial for preserving cultural heritage and promoting sustainable utilization of medicinal plants.