The present investigation documents the ethnobotanical knowledge and traditional therapeutic applications of medicinal plants utilized by local communities in Thalisain Block, District Pauri Garhwal, and Uttarakhand. A systematic field survey was conducted employing semi-structured interviews and participatory observations with traditional healers (Vaidhyas) and indigenous inhabitants. A total of 44 medicinal plant species belonging to 32 families were documented, with Lamiaceae, Asteraceae, and Fabaceae representing the dominant families. The documented species are traditionally employed for treating prevalent ailments including respiratory disorders, gastrointestinal conditions, dermatological infections, and musculoskeletal pain. Quantitative ethnobotanical indices revealed high use value for species such as Berberis asiatica, Zanthoxylum armatum, and Ajuga parviflora. This study underscores the necessity for conservation strategies and scientific validation of traditional phytotherapeutic practices to prevent erosion of indigenous knowledge systems and to facilitate sustainable utilization of medicinal plant resources in the Himalayan region.