In the present work, an attempt is made to document the Ethnobotanical studies on Agricultural Weed plants remedies for various ailments of the ethnic tribes inhabiting the Nirmal District of Telangana State, India. We reported 56 Ethnobotanical Common agricultural weed plants belonging to 25 families used by tribal people to alleviate diseases. Among these families, 53 are dicotyledons, and 3 are monocotyledons. The recorded weeds flora comprised 38 herbs, 6 creeping herbs, 2 climbers, 2 prostate herbs, and 2 shrubs. In addition, one species each was recorded under grass, sedge, twining herb, succulent herb, spiny herb, trailing herb categories. They are arranged in alphabetical order by scientific names for convenience, followed by family, local name in Telugu, habit, and Ethnobotanical use. Ethnobotanical weed medicine is the scientific term for healthcare practices in traditional methods. Weeds are generally considered undesirable plants in agricultural fields, but many possess significant medicinal, nutritional, fodder, and economic value. Nirmal district is rich in biodiversity and inhabited by tribal communities such as the Gonds, Lambada, Pradhans, Manne, Naikpods, Thoties, Yerikalas, and Kolams, who have preserved valuable traditional knowledge about the use of wild and common weed flora. Documenting this indigenous knowledge is essential for conserving biodiversity and promoting sustainable utilisation of plant resources. Ethnobotanical studies in and around Nirmal have documented extensive traditional use of wild plants, but the ethnobotanical importance of weed species specifically remains insufficiently explored. This area's forests are rich in biodiversity; many plants are traditionally used to prevent various infections and cure diseases.