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VOL. 7, ISSUE 1 (2022)
Anti-oxidative and hepatoprotective effects of methanolic extracts of seeds of Brassica nigra L., against CCL4 induced hepatic damage in HEPG2 cell lines
Authors
S Babyvanitha, K Vinothkumar, B Jaykar
Abstract
Accumulation of an excess amount of reactive oxygen species can cause hepatotoxicity that may result in liver damage. So development of antioxidant is needed for reducing liver toxicity. This study investigated the antioxidative and hepatoprotective activity of methanolic extract of seeds of Brassica nigra L., on carbon tetrachloride induced acute liver damage in vitro. The results of MTT assay indicated that methanolic extract of seeds of Brassica nigra L., was good antioxidant. The CCl4 exposed HepG2 cell line exhibited decreased cell viability, and elevated LPO, and decreased SOD, GSH and also increased the enzymes ALT, AST and LDH levels. Methanolic extract of seeds of Brassica nigra increased the cell viability and restoration of enzymes AST, ALT, LDH, and increased SOD, GSH levels and decreased the LPO and also restored the morphological changes of CCl4insulted HepG2celllines.
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Pages:542-546
How to cite this article:
S Babyvanitha, K Vinothkumar, B Jaykar "Anti-oxidative and hepatoprotective effects of methanolic extracts of seeds of<em> Brassica nigra </em>L., against CCL4 induced hepatic damage in HEPG2 cell lines ". International Journal of Botany Studies, Vol 7, Issue 1, 2022, Pages 542-546
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